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Vancomycin hydrochloride (Synonyms: 鹽酸萬古霉素)
Vancomycin hydrochloride 是用于研究細菌gan染 (bacterial) 的抗生su。 它通過抑制易感細菌的細胞壁合成的第二階段起作用。 Vancomycin hydrochloride 還改變細胞膜的滲透性并選擇性地抑制核糖核酸的合成。
生物活性
Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis
IC50 & Target：Bacterial[1]
體外研究(In Vitro)
Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococ
體內(nèi)研究(In Vivo)
Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].
分子量：1485.71
Formula：C66H76Cl3N9O24
CAS 號：1404-93-9
中文名稱：鹽酸萬古霉素
來源：Streptomyces orientalis
運輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式
4°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性數(shù)據(jù)
H2O : 33.33 mg/mL (22.43 mM; Need ultrasonic)
DMSO : 24 mg/mL (16.15 mM; Need ultrasonic and warming)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.6731 mL | 3.3654 mL | 6.7308 mL |
| 5 mM | 0.1346 mL | 0.6731 mL | 1.3462 mL |
| 10 mM | 0.0673 mL | 0.3365 mL | 0.6731 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
- 1.
請依序添加每種溶劑： PBS
Solubility: 130 mg/mL (87.50 mM); Clear solution; Need ultrasonic
- 3.
- 4.
參考文獻
Vancomycin hydrochloride (Synonyms: 鹽酸萬古霉素)
Vancomycin hydrochloride 是用于研究細菌gan染 (bacterial) 的抗生su。 它通過抑制易感細菌的細胞壁合成的第二階段起作用。 Vancomycin hydrochloride 還改變細胞膜的滲透性并選擇性地抑制核糖核酸的合成。
生物活性
Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis
IC50 & Target：Bacterial[1]
體外研究(In Vitro)
Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococ
體內(nèi)研究(In Vivo)
Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].
分子量：1485.71
Formula：C66H76Cl3N9O24
CAS 號：1404-93-9
中文名稱：鹽酸萬古霉素
來源：Streptomyces orientalis
運輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式
4°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性數(shù)據(jù)
H2O : 33.33 mg/mL (22.43 mM; Need ultrasonic)
DMSO : 24 mg/mL (16.15 mM; Need ultrasonic and warming)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.6731 mL | 3.3654 mL | 6.7308 mL |
| 5 mM | 0.1346 mL | 0.6731 mL | 1.3462 mL |
| 10 mM | 0.0673 mL | 0.3365 mL | 0.6731 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
- 1.
請依序添加每種溶劑： PBS
Solubility: 130 mg/mL (87.50 mM); Clear solution; Need ultrasonic
- 3.
- 4.
參考文獻
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